Basic Synthroid Information

• INN (International Nonproprietary Name)
• Brand names available in Canada
• ATC Code
• Forms & dosages (e.g., tablets, injections, creams)
• Manufacturers in Canada
• Registration status in Canada
• OTC / Rx classification

International Nonproprietary Name (INN)

The international nonproprietary name for this medication is Levothyroxine sodium. Levothyroxine is the active ingredient used to treat conditions related to thyroid hormone deficiencies. Most individuals are familiar with it under the brand name Synthroid in Canada, while Eltroxin is another option available for patients.

Brand Names Available In Canada

Synthroid and Eltroxin are the primary brand names you'll find in Canada. These medications come in various formulations and strengths, catering to individual patient needs. Typically, both products offer oral tablets, allowing for easy daily intake. It's essential to understand that consistent use of the same brand is recommended for stable hormone levels.

ATC Code

The ATC code for Levothyroxine is H03AA01. This classification signifies its role as a systemic hormonal thyroid preparation. Levothyroxine acts as a synthetic form of thyroxine (T4), a hormone that is crucial for regulating metabolism, growth, and development. Such categorization helps within healthcare systems to easily identify the drug family and its intended therapeutic purposes.

Dosage Forms

Synthroid is available primarily in oral tablets, and in select markets, as an oral liquid. Below is a summary of the available strengths:

Manufacturers

Several reputable companies manufacture Levothyroxine in Canada. AbbVie produces Synthroid, while other manufacturers include Mylan, Pfizer, and Merck KGaA. Availability of generic options also exists, allowing patients to choose affordable alternatives without compromising quality.

Registration Status

Levothyroxine has received widespread approval from health authorities, including FDA and EMA. In Canada, updates confirm its continued registration, supporting its efficacy and safety as a vital treatment option for thyroid hormone replacement.

OTC/Rx Classification

This medication is classified as prescription-only (Rx) in Canada. This classification emphasizes the importance of healthcare professionals' guidance when using Synthroid. Such oversight ensures patient safety, proper dosing, and monitoring of potential side effects, ultimately leading to better outcomes in thyroid management.

Dosage & Administration

Understanding the dosage of Synthroid is crucial for effective treatment. For adults starting on Synthroid to manage hypothyroidism, typical doses begin at 25 to 50 mcg daily. Adjustments are made based on thyroid-stimulating hormone (TSH) levels, with regular monitoring every four to six weeks until optimal levels are achieved. For full hormone replacement, an average of 1.6 mcg per kilogram of body weight is expected.

Different demographics warrant careful adjustments. In children, especially neonates with severe hypothyroidism, the dose starts lower at 10 to 15 mcg per kilogram daily. For older adults, a lower starting dose, typically around 12.5 to 25 mcg, is advisable to reduce the risk of cardiovascular issues. No major adjustments are needed for patients with mild liver or kidney impairments; however, they should be closely monitored.

Treatment with Synthroid often becomes a lifelong commitment, particularly in cases of primary hypothyroidism. It is essential to store Synthroid tablets at temperatures between 20 to 25 degrees Celsius, keeping them protected from light and moisture. When transporting this medication, always keep it in its original packaging to maintain its potency during travel.

Safety & Warnings

Knowing the safety profile of Synthroid is essential for effective disease management. Absolute contraindications include untreated thyrotoxicosis, untreated adrenal insufficiency, recent myocardial infarction, and hypersensitivity reactions to the medication or its excipients. On the other hand, relative contraindications warrant careful monitoring. These include diabetes, cardiovascular disease (angina or coronary artery disease), elderly patients at risk for cardiac events, osteoporosis, and those who have undergone major surgery recently.

Common side effects of Synthroid range from mild issues like headaches, nervousness, and insomnia to more serious effects like palpitations and increased blood pressure. Most of these adverse reactions typically arise from over-replacement rather than the medication itself. Special precautions are advised for pregnant people and individuals with liver or kidney dysfunction. Consistent monitoring is crucial.

One particularly significant risk associated with Synthroid is included in its black box warning, advising patients about potential life-threatening risks associated with overdose, such as chest pain and confusion, which require immediate medical attention.

Patient Experience

Glimpses into patient experiences with Synthroid often reflect both positive outcomes and concerns. Reviews gathered from platforms like Drugs.com, Reddit, and WebMD reveal that many individuals report significant improvements in energy levels and overall well-being after initiating treatment. However, there's a notable mention of side effects that can arise, such as anxiety and heart palpitations.

User feedback reveals mixed feelings. Some users praise the improvement in mental clarity and energy, highlighting how Synthroid made a difference in managing their symptoms. Others express concerns about adjusting to the correct dosage, emphasizing that achieving stability requires patience and regular communication with health care providers.

Common themes emerge regarding effectiveness and tolerability. Positive remarks about Synthroid's reliability contrast with apprehensions about side effects, especially during dosage adjustments. It’s clear that patient experiences span a range of emotions but often converge on the importance of individualized treatment plans and ongoing interactions with healthcare professionals.

Alternatives & Comparison

Patients often seek alternatives to Synthroid, and in Canada, two notable options include Eltroxin and Levoxyl. Eltroxin, also containing levothyroxine, has been widely used and is known for its stability and effectiveness. Levoxyl is another alternative and is preferred by some for its minimal inactive ingredients, which can reduce the risk of allergies or intolerances.

Doctors often show a preference for Synthroid due to its long-standing reputation and adherence to strict quality standards. The consistent results and the body of clinical evidence supporting its use generally lead healthcare professionals to recommend Synthroid over its alternatives.

Market Overview (Canada)

Synthroid is easily accessible in major pharmacy chains like Shoppers Drug Mart and Rexall, as well as various online pharmacies. This broad availability ensures patients can find what they need without hassle.

On average, Synthroid costs between $20 to $35 CAD per month, depending on the dosage and pharmacy deals. Eltroxin is typically cheaper, ranging from $15 to $30 CAD, while Levoxyl costs more due to limited availability, averaging $25 to $40 CAD.

In terms of packaging, Synthroid is typically sold in blister packs or bottles, with options available in various strengths to accommodate different dosing needs. Seasonal trends show higher demand during the fall and winter months, possibly due to increased thyroid-related health issues or medication refills after summer vacations.

Research & Trends

Recent meta-analyses have highlighted that personalized dosing of levothyroxine may yield better outcomes, especially in older adults. Insights from trials conducted between 2022 and 2025 suggest that the standard 1.6 mcg/kg/day dosage may not suit all demographics. Tailoring doses based on weight and age is becoming a focus.

Innovative studies explore experimental uses of Synthroid beyond hypothyroidism, targeting potential applications in weight management and cognitive enhancement, albeit with caution. These new applications are met with excitement but require more robust data before standardizing protocols.

As for patents, Synthroid remains under patent protection, but several generics are available, including Eltroxin. This provides patients with options at varying price points while still maintaining similar therapeutic effects, reflecting a dynamic market adjusted to patient needs and accessibility.

Guidelines for Proper Use

Timing is crucial when taking Synthroid. It’s important to take it on an empty stomach, usually 30-60 minutes before breakfast, with a full glass of water. This maximizes absorption and effectiveness.

Avoid substances that can interfere with Synthroid’s action. Common culprits include calcium supplements and iron-containing products. To enhance effectiveness, separate their intake from Synthroid by at least four hours.

• Store Synthroid in a cool, dry place away from light.
• Keep it at room temperature, ideally between 20–25°C (68–77°F).
• Ensure it is out of reach of children and pets.

Common mistakes include taking the medication with food or drinks like coffee, which can hinder absorption. Missing doses is another common issue; however, if you do, take it as soon as you remember unless it’s close to the next scheduled dose.

Always refer to the patient leaflet provided with Synthroid for comprehensive instructions and consult with healthcare professionals for clarity on any concerns.