Sinequan
Sinequan
- In our pharmacy, you can buy Sinequan (doxepin) by prescription only, with availability in the Canada, UK, and export markets.
- Sinequan is used for the treatment of depression and anxiety. It works as a non-selective monoamine reuptake inhibitor, affecting neurotransmitters in the brain.
- The usual dosage for depression or anxiety starts at 75 mg per day, with a range of 75-150 mg, and a maximum dose of up to 300 mg per day.
- The form of administration is capsules, available in strengths of 10 mg, 25 mg, 50 mg, 75 mg, and 100 mg.
- The effect of the medication may begin within 1–3 weeks.
- The duration of action can vary, often lasting several months up to 1 year depending on individual response.
- Do not consume alcohol while taking Sinequan, as it may increase side effects.
- The most common side effect is drowsiness.
- Would you like to try Sinequan without a prescription?
Basic Sinequan Information
- INN (International Nonproprietary Name): Doxepin
- Brand names available in Canada: Sinequan, Silenor, Quitaxon, Doquel
- ATC Code: N06AA12
- Forms & dosages: Capsules, oral solution, tablets
- Manufacturers in Canada: Mylan, Teva, local generics
- Registration status in Canada: Prescription only
- OTC / Rx classification: Prescription only (Rx)
International Nonproprietary Name (INN)
Doxepin is the International Nonproprietary Name for a medication commonly used for its antidepressant and anxiolytic properties.
Brand Names Available in Canada
In Canada, Doxepin is marketed under various brand names, including:
- Sinequan: Capsules used primarily for major depressive episodes.
- Silenor: Tablets designed specifically for treating insomnia.
- Quitaxon: Available in Spain.
- Doquel: Primarily found in Australia.
ATC Code and Classification
Doxepin is categorized under ATC Code N06AA12. This classification places it in the group of psychoanaleptics and antidepressants, specifically as a non-selective monoamine reuptake inhibitor. This means that it works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine in the brain, thus enhancing their availability and helping to regulate mood.
Forms and Dosages Available
The medication is available in several dosage forms, making it versatile for different therapeutic needs:
| Form | Strength (mg) |
|---|---|
| Capsules | 10mg, 25mg, 50mg, 75mg, 100mg |
| Oral Solution | 10 mg/mL |
| Tablets | 3mg, 6mg (as Silenor) |
Manufacturers and Suppliers
Doxepin is manufactured and supplied by various companies including Mylan and Teva, as well as local generic producers in Canada. This availability ensures that patients can access the medication with relative ease.
Registration Status in Canada
In Canada, all forms of Doxepin are classified as prescription only (Rx). While the Sinequan brand has been discontinued in some regions, generics are available, providing patients with affordable options.
Dosage & Administration of Sinequan
When it comes to taking Sinequan (doxepin), understanding dosage and administration is crucial for maximizing its benefits while minimizing potential side effects. Here’s what to know.
Typical Dosage by Condition
For adults experiencing depression or anxiety, the standard starting dose is typically around 75 mg per day. This may be taken in divided doses or as a single nightly dose. Dosage can range from 75 to 150 mg daily, depending on individual response, with a maximum cap at 300 mg per day.
If insomnia is the main concern, Sinequan's formulation as Silenor is recommended. The typical starting dosage is between 3 to 6 mg taken just before bedtime.
Adjustment Guidelines for Age/Comorbidities
Age and overall health play a vital role in determining appropriate dosages. For elderly patients, starting at the lower end of the dosage range, between 25 to 50 mg per day, is advisable due to increased sensitivity to side effects.
Patients with liver or renal impairments should also start with a reduced dose. Close monitoring and gradual adjustments are necessary to ensure safe usage.
Treatment Duration & Storage
Monitoring is essential; while patients might start to feel improvements in 1 to 3 weeks, treatment duration can vary greatly, often extending from several months to even a year. It is important to assess progress regularly.
When it comes to storing Sinequan, keep it at room temperature, away from moisture and direct heat. Maintaining the original packaging during transport is essential to prevent contamination.
Missed Dose/Overdose Guidelines
If a dose is missed, take it as soon as possible, unless it’s almost time for the next one. In such cases, just skip the missed dose—never double up. If an overdose is suspected, symptoms like severe drowsiness or confusion could appear. Immediate medical assistance is crucial.
Safety & Warnings for Sinequan
Understanding the safety profile of Sinequan is important for preventing adverse effects and ensuring proper treatment. Below are key safety considerations.
Contraindications
Some absolute contraindications include hypersensitivity to doxepin, narrow-angle glaucoma, urinary retention, and concurrent use with MAO inhibitors, which can lead to serious interactions. Relative contraindications also exist for the elderly, due to heightened risks like confusion and falls.
Side Effects
Common side effects affecting users include drowsiness, dry mouth, dizziness, and blurred vision. While these symptoms are generally mild to moderate, severe reactions—such as cardiac arrhythmias or seizures—require immediate attention. Reporting any severe side effects is critical for ensuring patient safety.
Special Precautions
For special populations, such as pregnant or lactating individuals, the medication should only be used when truly necessary and under specialist guidance. Those with liver or kidney issues should also approach treatment with caution.
Black Box Warnings
As of now, Sinequan does not carry a black box warning, but that doesn't mean users should take it lightly. Always consult a healthcare provider and monitor any ongoing health issues closely.
Patient Experience with Sinequan
Understanding what real users have to say about Sinequan can provide insight into its effectiveness and tolerability. Here’s a summary of user experiences.
Reviews and Feedback
Average user ratings for Sinequan often hover around positive to neutral, reflecting mixed experiences. Many appreciate the medication's efficacy in managing anxiety and depression but point out variability in side effects.
User Testimonials
Testimonials reveal insights into both the advantages and drawbacks of Sinequan. Users have highlighted its effectiveness in alleviating anxiety symptoms. However, some have reported issues like fatigue and dry mouth, leading to varied adherence to their prescribed regimen.
Qualitative Insights
The emotional benefits reported often include a sense of calm and increased mood stability. Users suggest that for many, Sinequan can serve as a helpful tool in their mental health journey, improving overall quality of life.
Alternatives & Comparison of Sinequan
When looking for alternatives to Sinequan (doxepin) in Canada, several medications come to mind. Amitriptyline and Sertraline are among the most common options. Amitriptyline is often used for both depression and chronic pain, while Sertraline is a popular selective serotonin reuptake inhibitor (SSRI) for anxiety and depression.
| Medication | Price (CAD) | Effectiveness | Safety | Availability |
|---|---|---|---|---|
| Sinequan | $25 - $60 | Moderate | Side effects can include drowsiness | Prescription only |
| Amitriptyline | $10 - $40 | High | Commonly well-tolerated | Widely available |
| Sertraline | $30 - $55 | High | Lower risk for side effects | Widely available |
Locally, healthcare professionals may lean towards prescribing Sertraline first due to its favorable side-effect profile, despite Sinequan having its advantages in treating specific conditions like insomnia.
Market Overview for Sinequan
Sinequan is available at most major pharmacies across Canada, including Catena, HelpNet, and Shoppers Drug Mart. The price generally falls between $25 and $60, depending on dosage and pharmacy.
Packaging typically includes both blister packs and bottles, with the dosages ranging from 10 mg to 100 mg capsules. Demand patterns show that usage spikes in winter, correlating with seasonal depression and insomnia. Chronic conditions such as anxiety and depression keep the medication in consistent demand throughout the year.
Research & Trends for Sinequan
Recent studies from 2022 to 2025 have focused on the efficacy and safety of doxepin, highlighting its effectiveness in treating insomnia and certain anxiety disorders. Emerging research is exploring its potential role in other conditions like chronic pain and fibromyalgia.
The patent for Sinequan has expired, leading to a variety of generic alternatives becoming available in Canada, making the medication more accessible to patients. This opens doors for lower-cost options, prompting increased interest in doxepin's clinical uses.
Guidelines for Proper Use of Sinequan
To get the best results from Sinequan, it's crucial to take the medication as prescribed. Typically, it’s best taken at bedtime, with or without food. Ensure to drink plenty of water.
Avoid combining Sinequan with alcohol, certain medications, or other substances that may cause drowsiness, such as antihistamines.
Store it at room temperature, away from moisture and heat, and avoid leaving it in places like a bathroom or kitchen. Some common mistakes include not staying consistent with dosing or not consulting with a healthcare professional about potential interactions.
Always refer back to the patient leaflet for personalized instructions and reach out to a healthcare provider with any questions.