Medroxyprogesterone
Medroxyprogesterone
- In our pharmacy, you can buy Medroxyprogesterone without a prescription, with delivery available in many regions worldwide. Discreet and anonymous packaging.
- Medroxyprogesterone is used primarily for contraception and treating various gynecological disorders; it works as a progestin hormone that regulates the menstrual cycle and interferes with ovulation.
- The usual dosage for contraception is 150 mg via intramuscular injection every 3 months or 104 mg via subcutaneous injection every 3 months. For endometriosis, it is typically 5–10 mg oral daily for 5–10 days.
- The form of administration includes oral tablets, intramuscular suspensions, and subcutaneous injections.
- The effect of the medication begins within a few days for oral tablets, while injections may take about 24 hours to 3 days to take effect.
- The duration of action for the injectable form is approximately 12–13 weeks.
- Do not consume alcohol while using Medroxyprogesterone as it may increase the risk of side effects.
- The most common side effect is menstrual irregularities, such as changes in flow or amenorrhea.
- Would you like to try Medroxyprogesterone without a prescription?
Basic Medroxyprogesterone Information
- INN (International Nonproprietary Name)
- Brand names available in Canada
- ATC Code
- Forms & dosages (e.g., tablets, injections, creams)
- Manufacturers in Canada
- Registration status in Canada
- OTC / Rx classification
What Is Medroxyprogesterone?
Medroxyprogesterone is the International Nonproprietary Name (INN) for a synthetic progestin. This medication plays a vital role in women's reproductive health. As a type of hormone, it’s pivotal in regulating various bodily functions, including the menstrual cycle. Understanding its function is crucial, especially for those considering it for contraceptive or therapeutic purposes.
Brand Names Available in Canada
In Canada, Medroxyprogesterone is marketed under several brand names. The most well-known brands include:
- Depo-Provera: Administered as an injection, typically in a strength of 150 mg/mL.
- Provera: Available as oral tablets in strengths of 2.5 mg, 5 mg, and 10 mg.
These medications may come in different packaging, including single-use vials or blister packs.
ATC Code And Dosage Forms
Medroxyprogesterone is classified under specific ATC codes:
- G03AC06: Progestogens for systemic use
- L02AB02: Progestogens in endocrine therapy
- G03DA02: Pregnen derivatives for reproductive hormone use
Medroxyprogesterone is available in various forms in Canada as outlined in the table below:
| Form | Strengths | Typical Packaging |
|---|---|---|
| Oral Tablet | 2.5 mg, 5 mg, 10 mg | Blister strips, bottles |
| IM Suspension (Depo) | 150 mg/mL | Pre-filled syringe, vial |
| Subcutaneous Injection | 104 mg/0.65 mL | Prefilled syringe |
| Other Combined Products | Varies | 28-day tablet packs |
Manufacturers And Registration Status
Pfizer is a key manufacturer of Medroxyprogesterone, specifically for its brand Depo-Provera. Other companies like Teva and Mylan also produce generic versions. The medication has received approval from global health authorities, including:
- FDA (United States)
- EMA (Europe)
It is classified as a prescription-only medication in many regions, including Canada, due to its use in hormone replacement and contraceptive therapies. Understanding the registration status can help patients ensure they are using a trusted product.
Dosage & Administration
When it comes to taking Medroxyprogesterone, understanding the proper dosage is key for maximizing benefits and minimizing risks. Numerous conditions can be treated with this medication, and knowing the standard dosages is essential for effective management.
Typical Dosage by Condition
Finding the right dosage for Medroxyprogesterone can vary significantly based on the condition being treated. Below is a table outlining common dosages:
| Indication | Dosage & Route | Regimen |
|---|---|---|
| Contraception (IM) | 150 mg IM every 3 months | Single injection |
| Contraception (SubQ) | 104 mg SC every 3 months | Single injection |
| Endometriosis, Uterine Bleeding | 5–10 mg oral daily for 5–10 days | Cyclic (typically days 16–21) |
| Endometrial Cancer | 200–400 mg IM weekly | Individualized therapy |
| Secondary Amenorrhea | 5–10 mg oral daily for 5–10 days | Cyclic, repeat as needed |
Adjustments for Age or Comorbidities
Dosage adjustments might be necessary based on individual health factors:
- Children: Use under specialist guidance. It's not recommended for routine pre-puberty use due to limited safety data.
- Elderly: Dose adjustments are generally not available; use only for approved indications.
- Liver/Kidney Impairments: Exercise caution, as Metabolism is hepatic and may require dose adjustment.
Treatment Duration, Storage, Transport
How long treatment lasts varies. For contraception, injections are typically repeated every 12-13 weeks. Gynecological uses may require a course of a few days. For cancer treatment, it can continue until disease progression.
Storage is straightforward:
- Keep at room temperature (15–25°C).
- Avoid exposure to light and freezing conditions.
- Check for clumping or discoloration before use.
Safety & Warnings
Safety is a priority when taking Medroxyprogesterone. Awareness of contraindications and potential side effects can prevent adverse outcomes.
Contraindications
There are specific conditions where Medroxyprogesterone should not be used:
- Known or suspected pregnancy
- Active thromboembolic disease
- Unexplained vaginal bleeding
- Known breast or genital cancer
- Severe liver dysfunction
- Allergic reactions to active ingredients
Side Effects
Patients often report various side effects while using Medroxyprogesterone, which can be categorized as follows:
- Common Side Effects: Weight gain, menstrual irregularities, headaches.
- Moderate Side Effects: Mood changes, dizziness, nausea.
- Severe Reactions: Signs of thromboembolic events, severe allergic reactions.
Black Box Warnings
Some warnings apply to Medroxyprogesterone:
- Increased risk of thromboembolism in women who smoke.
- Careful monitoring for significant depression.
Patient Experience
Understanding the patient experience with Medroxyprogesterone can provide valuable insights into what to expect.
Reviews and Feedback
Online platforms like Drugs.com, Reddit, and WebMD reveal mixed reviews from users:
- Many users describe effective symptom management for menstrual issues.
- Others report concerns about side effects like weight gain and mood swings.
- Overall satisfaction varies, with some users expressing the need for better communication from healthcare providers.
User Insights
Forums and discussions show common themes in user feedback:
- Effectiveness in managing conditions such as endometriosis and as a contraceptive.
- Side effects, particularly mood changes and irregular cycles, are frequently highlighted.
- Sharing of personal experiences aids others in managing their expectations.
Common Alternatives in Canada
When considering alternatives to Medroxyprogesterone, several options are popular among patients and healthcare providers in Canada. Notably, Norethisterone (norethindrone) is often prescribed for menstrual regulation and contraception. Another alternative, Levonorgestrel, is available in both oral and implant forms, providing flexibility in contraceptive options. Additionally, Desogestrel is gaining attention as a progestin with a unique profile that may suit different needs.
These alternatives offer varying efficacy and side effects, making it crucial for patients to discuss their healthcare goals with their doctors. Weighing these options allows for a more tailored approach to hormone therapy.
Comparison Table
| Medication | Average Price (CAD) | Effectiveness | Safety Profile |
|---|---|---|---|
| Medroxyprogesterone | $25 | 94-99% | Generally well-tolerated |
| Norethisterone | $20 | 90-95% | May cause menstrual irregularities |
| Levonorgestrel | $30 | 95-99% | Common side effects include nausea |
| Desogestrel | $35 | 92-99% | Fewer side effects reported |
Doctor Preferences
Healthcare providers across Canada often have differing preferences when it comes to prescribing alternatives to Medroxyprogesterone. Some doctors favor Norethisterone for its historical effectiveness and established profile. Others may recommend Levonorgestrel for patients seeking a hormonal implant, emphasizing convenience and compliance. Desogestrel is also becoming increasingly popular among practitioners who favor a newer progestin with potentially fewer side effects. Ultimately, these preferences can vary significantly based on individual patient needs, medical history, and the recommended treatment protocols.
Availability in Pharmacies
Accessing Medroxyprogesterone in Canada is generally straightforward, with major pharmacies like Catena and HelpNet stocking it regularly. Patients can find this medication in both oral and injectable forms, ensuring a suitable option for various treatment plans. Availability tends to fluctuate based on regional supply, but overall, most urban pharmacies carry it consistently.
Average Price
The average cost for Medroxyprogesterone is approximately $25 CAD, depending on the pharmacy. Patients with insurance may find that their plans cover a portion of this expense, thus reducing out-of-pocket costs. It's worth contacting your insurance provider to understand what reimbursement options are available, as these can vary significantly by plan.
Packaging & Demand Patterns
Medroxyprogesterone is usually packaged in blister strips for oral tablets or as pre-filled syringes for injections. Recent trends indicate that demand for this medication rises during certain health crises, like public health initiatives promoting family planning. Patients may also prefer using Medroxyprogesterone during specific periods of their reproductive health journey, like postpartum care or managing endometriosis symptoms.
Recent Trials / Meta-analyses
Recent studies focusing on Medroxyprogesterone have emerged, highlighting its safety and efficacy in various applications, particularly in contraception and managing endometriosis symptoms. Trials conducted between 2022 and 2025 emphasize the medication’s reliability in preventing unintended pregnancies and its role in hormonal balance.
Noteworthy findings showcase consistent effectiveness across diverse patient populations, cementing Medroxyprogesterone’s place in modern hormone therapy. Ongoing research continues to evaluate its long-term safety and potential new applications.
Experimental Uses
Outside conventional uses, some experimental treatments are gaining traction with Medroxyprogesterone. Off-label uses, such as treating particular hormone-responsive cancers or aiding in body weight management, are under exploration. These studies may present new horizons for Medroxyprogesterone, allowing it to assist in broader health contexts.
Patent Status & Generics
As of now, Medroxyprogesterone remains under patent but has generics available in the market from reliable manufacturers. This accessibility helps mitigate costs for patients and enhances medication availability. Ongoing developments in the generics market reflect a growing push for affordability among essential medications, ensuring that patients have options.