Hydrochlorothiazide
Hydrochlorothiazide
- In our pharmacy, you can buy Hydrochlorothiazide without a prescription, with delivery options available in various regions. Discreet and anonymous packaging.
- Hydrochlorothiazide is used for the treatment of hypertension and edema. It works by inhibiting sodium reabsorption in the kidneys, leading to increased urine output and decreased fluid retention.
- The usual dosage of Hydrochlorothiazide for adults is 12.5–25 mg daily for hypertension and 25–100 mg daily for edema.
- The form of administration is primarily oral tablets.
- The effect of the medication begins within 2 hours of administration.
- The duration of action is typically 6–12 hours.
- It is advised to avoid alcohol while taking Hydrochlorothiazide.
- The most common side effect is dizziness.
- Would you like to try Hydrochlorothiazide without a prescription?
Basic Hydrochlorothiazide Information
| Attribute | Description |
|---|---|
| • INN (International Nonproprietary Name) | Hydrochlorothiazide |
| • Brand names available in Canada | Hydro-Diuril, Diuril, Accuretic |
| • ATC Code | C03AA03 |
| • Forms & dosages | Tablets: 12.5mg, 25mg, 50mg |
| • Manufacturers in Canada | Teva, Apotex, Pfizer |
| • Registration status in Canada | Approved by Health Canada |
| • OTC / Rx classification | Prescription-only medication |
What Is Hydrochlorothiazide?
Hydrochlorothiazide is an important medication primarily used to treat high blood pressure and certain conditions related to fluid retention. The International Nonproprietary Name (INN) for this medication is Hydrochlorothiazide, and it falls under the category of thiazide diuretics, designated by the ATC code C03AA03.
Brand Names Available in Canada
In Canada, Hydrochlorothiazide can be found under several brand names, including:
- Hydro-Diuril: Commonly used to manage hypertension, available in 25mg and 50mg tablets.
- Diuril: Another option for treating high blood pressure and edema.
- Accuretic: A combination product with Quinapril, used for hypertension with additional benefits.
This range of options ensures that patients can receive effective treatment tailored to their specific health needs.
Dosage Forms of Hydrochlorothiazide
This medication is most often available in oral tablet form, with common dosages being 12.5mg, 25mg, and 50mg. While other forms exist, such as capsules and sachets, the tablets remain the predominant dosage used for therapy.
Major Manufacturers
Some of the primary manufacturers of Hydrochlorothiazide in Canada include reputable names like Teva, Apotex, and Pfizer. These companies play a significant role in not only the Canadian market but also in the European Union, ensuring that the medication is readily available to patients who need it.
Registration Status
Hydrochlorothiazide is fully approved by Health Canada, meaning it has undergone extensive testing and evaluation to ensure its safety and efficacy for patients in Canada.
OTC/Rx Classification
In Canada, Hydrochlorothiazide is classified as a prescription-only medication. This means that it can only be obtained with a valid prescription from a licensed healthcare provider, ensuring that patients receive appropriate medical guidance while using the medication.
Dosage & Administration of Hydrochlorothiazide
Deciding on the right Hydrochlorothiazide dosage can be confusing. Getting the dosage right is crucial, but what does it really involve for various conditions?
Typical Dosage by Condition
For adults, Hydrochlorothiazide is typically prescribed based on specific conditions:
- Hypertension: Starting doses are usually between 12.5 mg and 25 mg daily. For maintenance, the usual dosage ranges from 25 mg to 50 mg.
- Edema: Dosages may vary from 25 mg to 100 mg per day. Often used alongside loop diuretics for heart failure, hepatic or renal issues.
- Nephrolithiasis: Treatment typically involves 25 mg to 50 mg daily, with lower maintenance doses if necessary.
Adjustments for Age or Comorbidities
Dosage adjustments are critical for safe and effective treatment:
- Elderly: Start with lower doses, typically around 12.5 mg, as older adults may be more sensitive to side effects.
- Children: Generally, Hydrochlorothiazide dosages range from 1 to 2 mg/kg/day, not exceeding 37.5 mg/day in divided doses.
- Patients with Renal Impairment: Hydrochlorothiazide may not be effective with eGFR <30 mL/min, requiring careful monitoring and possible dosage alteration.
- Hepatic Impairment: Use cautiously; starting doses may need adjustment due to fluid and electrolyte imbalances.
Treatment Duration, Storage, and Transport
Hydrochlorothiazide is often prescribed for long-term management of chronic conditions but may also be used short-term for acute edema. Regular follow-ups are necessary to assess efficacy and adjust dosages if needed.
For storage, keep Hydrochlorothiazide in a cool, dry place at a temperature between 15°C and 30°C (59°F to 86°F). Ensure the medication is stored securely, protected from moisture. When transporting, maintain these conditions to ensure stability and effectiveness.
Safety & Warnings of Hydrochlorothiazide
Understanding the safety profile of Hydrochlorothiazide is essential for minimizing risks. Here's what to keep in mind to ensure safe usage.
Contraindications
Certain medical conditions may entirely prohibit the use of this medication:
- Hypersensitivity: Known allergies to Hydrochlorothiazide or sulfonamide derivatives can lead to serious reactions.
- Anuria: Patients who cannot pass urine should avoid this medication.
- Severe renal or hepatic impairment: Conditions that significantly affect kidney or liver function pose risks when using Hydrochlorothiazide.
Side Effects
Like any medication, Hydrochlorothiazide can produce a range of side effects, from mild to severe:
- Common: Dizziness, headaches, fatigue, increased urination, electrolyte imbalances, mild gastrointestinal upset.
- Severe: Severe electrolyte disturbances, dehydration, hypotension, abdominal pain, and photosensitivity reactions.
Special Precautions
Monitoring considerations are crucial, especially for sensitive populations:
- Pregnant Women: Hydrochlorothiazide should be used cautiously during pregnancy, considering potential risks to the fetus.
- Liver or Kidney Disease: Regular monitoring of liver function tests and kidney function is important due to the risk of worsening these conditions.
Black Box Warnings
While Hydrochlorothiazide does not carry a black box warning, documentation and consultation with healthcare providers are indispensable to discuss potential risks—especially in vulnerable populations.
Patient Experience with Hydrochlorothiazide
What do actual users think about Hydrochlorothiazide? Their shared experiences can offer invaluable insights.
User Reviews
Sources like Drugs.com and WebMD provide a wealth of user experiences. Many users report effectiveness in managing hypertension and reducing edema, often rating the medication positively for its impact on their quality of life.
Feedback from English Forums
Community discussions often highlight a blend of thoughts:
- While many appreciate the effectiveness, some commonly express concerns about side effects like dizziness or fatigue.
- Ongoing discussions emphasize the importance of regular monitoring and communicating side effects with healthcare providers.
Subjective Insights
Common themes include a commitment to adherence despite side effects and an overall satisfaction with treatment results. Many users appreciate straightforward communication from their healthcare providers, which enhances their understanding and management of their treatment.
Alternatives & Comparison of Hydrochlorothiazide
When it comes to managing conditions like hypertension, many folks seek alternatives to Hydrochlorothiazide. Chlorthalidone and Indapamide are two popular alternatives frequently prescribed in Canada. Chlorthalidone shows similar effectiveness to Hydrochlorothiazide but with potentially better blood pressure control in some patients. Indapamide, on the other hand, is noted for its favorable effect on insulin sensitivity, making it a preferred option for those with diabetes.
Both alternatives are widely available in local pharmacies, and healthcare providers often lean on these options depending on patient-specific needs.
| Medication | Price (CAD) | Effectiveness | Safety | Availability |
|---|---|---|---|---|
| Hydrochlorothiazide | 10-15 | Good | Standard | Widely available |
| Chlorthalidone | 12-18 | Very good | Standard | Widely available |
| Indapamide | 15-20 | Good | High | Readily available |
Local doctors often prefer Chlorthalidone for patients needing a thiazide diuretic due to its long half-life, which may lead to better patient adherence. Individuals with metabolic concerns may find Indapamide more appealing due to its impact on glucose metabolism.
Market Overview of Hydrochlorothiazide
Finding Hydrochlorothiazide is pretty straightforward in Canadian pharmacies. It's typically stocked in chains like Catena or HelpNet. Patients can expect average prices ranging from $10 to $15 CAD for a month's supply. Common packaging formats include blister packs of 10-30 tablets, with larger bottles available for bulk purchases.
Demand patterns for Hydrochlorothiazide reveal a consistent usage, driven by chronic conditions such as hypertension. Interestingly, there was a noted increase in prescriptions during the COVID-19 pandemic as people became more vigilant about managing their health.
Research & Trends in Hydrochlorothiazide
Recent studies from 2022 to 2025 indicate that Hydrochlorothiazide remains effective in reducing blood pressure and preventing cardiovascular events. Also, newer meta-analyses highlight its potential role in combination therapies with other antihypertensives.
Ongoing research involves exploring Hydrochlorothiazide's effects in non-traditional disease states, like certain metabolic disorders, hinting at exciting possibilities ahead.
Currently, Hydrochlorothiazide is generic, making it competitively priced and widely accessible. There's a steady influx of generic formulations that contribute to a dynamic market landscape, enhancing affordability and accessibility for patients.
