Diltiazem
Diltiazem
- Diltiazem can be purchased with a prescription at pharmacies across the United States, and it is also available through international e-pharmacies.
- Diltiazem is used primarily for the treatment of essential hypertension and chronic stable angina by acting as a calcium channel blocker to lower blood pressure and improve blood flow to the heart.
- The usual dosage for essential hypertension is initially 120–240 mg per day, divided into multiple doses.
- The form of administration includes film-coated tablets, extended-release tablets, injectables, and topical creams.
- The onset time for Diltiazem is approximately 30-60 minutes after oral administration.
- The duration of action is around 4-6 hours for immediate-release forms, while extended-release formulations can last up to 24 hours.
- It is advised to avoid alcohol consumption while taking Diltiazem due to potential interactions.
- The most common side effect is edema, particularly in the ankles and feet.
- Would you like to try Diltiazem without a prescription?
Diltiazem
Basic Diltiazem Information
- INN (International Nonproprietary Name): Diltiazem
- Brand names available in Canada: Cardizem®, Tiazac®
- ATC Code: C08DB01, C05AE03
- Forms & dosages: Film-coated tablets, extended-release capsules, injectables, topical creams
- Manufacturers in Canada: Mylan, Pfizer, and others
- Registration status in Canada: Prescription-only (Rx)
What Is Diltiazem?
Diltiazem is the generic name recognized worldwide for a medication used primarily to treat certain heart and blood vessel conditions. As a calcium channel blocker, this medication effectively helps relax blood vessels, making it a crucial option for individuals with hypertension or angina.
Common Brand Names for Diltiazem in Canada
In Canada, notable brands include:
- Cardizem®
- Tiazac®
These brand names reflect varying formulations available for patients, ensuring accessibility based on specific healthcare needs.
ATC Code and Classifications
Diltiazem falls under the ATC Code:
| ATC Code | Classification | Description |
|---|---|---|
| C08DB01 | Calcium channel blocker, benzothiazepine derivative | Oral systemic use in treating cardiovascular conditions |
| C05AE03 | Vasoprotective | Topical use for conditions like anal fissures |
Available Dosage Forms
Diltiazem comes in various forms to suit different patient needs, including:
| Form | Dosages | Packaging |
|---|---|---|
| Film-coated tablets | 30 mg, 60 mg, 90 mg, 120 mg | Available in blisters of 10, 30, 60, or 100 |
| Extended-release capsules | 120 mg, 180 mg, 240 mg, 300 mg, 360 mg | Found in cartons or bottles |
| Injectables | 5 mg/mL, 25 mg/5mL, 50 mg/10mL | Ampoules for hospital use |
| Topical cream | 2% diltiazem HCl | Tubes of 30g for anal fissures |
Manufacturers
In Canada and Europe, Diltiazem is produced by several notable manufacturers, such as:
- Mylan
- Pfizer
- Teva
These companies ensure a steady supply of Diltiazem, which can be crucial for consistent patient care.
Regulatory Status of Diltiazem
In Canada, Diltiazem is classified as a prescription-only medication. This ensures that it is dispensed under the guidance of a healthcare professional, emphasizing safe and effective use. Globally, Diltiazem has received various approvals from health authorities — like the FDA and EMA — reflecting its substantial medical credibility.
Dosage & Administration of Diltiazem
When prescribed diltiazem, understanding the correct dosage is crucial for effective treatment. For managing essential hypertension, typical dosages range from 120 to 240 mg daily, divided into two or three doses. In cases of chronic stable angina, dosages usually fall between 180 and 360 mg per day, often in divided doses as well.
Adjusting the diltiazem dosage may be necessary for different patient populations. The elderly should start at the lower end of the dosing range to minimize risks like hypotension and bradycardia. Patients with liver or renal impairment may also require dose modifications, but specific guidelines vary based on the severity of the dysfunction.
As for the duration of therapy, it typically spans a long-term commitment, especially for chronic cardiovascular conditions. Most patients may remain on diltiazem indefinitely, while topical applications for issues such as anal fissures often last between four to eight weeks.
Storing diltiazem properly is quite simple. Keep the tablets or capsules in a cool, dry place at a temperature between 20 to 25°C (68 to 77°F). Protect them from moisture and direct light, and be sure to refrigerate injectable forms if specified in the manufacturer's instructions.
Safety & Warnings for Diltiazem
Patients considering diltiazem should be aware of various contraindications. Absolute contraindications include hypersensitivity to the drug, conditions like sick sinus syndrome (without a pacemaker), severe hypotension, and acute myocardial infarction with pulmonary congestion. Relative contraindications exist for patients with congestive heart failure, mild bradycardia, or who are concurrently using beta-blockers.
Side effects can vary in severity. Common side effects include edema, headache, dizziness, and gastrointestinal upset. Rare but severe risks include bradycardia and severe hypotension. Those on diltiazem should be monitored closely, especially pregnant individuals or those with liver or kidney issues. Special precautions are warranted in these scenarios to ensure safety.
Regarding black box warnings, diltiazem does not currently have any, but this may vary by region. Always consult healthcare professionals for the latest safety information and tailored guidance.
Patient Experience with Diltiazem
When looking at patient reviews, diltiazem generally receives mixed feedback. Many users share experiences about its effectiveness in managing hypertension and angina symptoms. Platforms like Drugs.com and Reddit highlight how diltiazem helps maintain stable blood pressure, significantly when combined with lifestyle changes.
However, side effects are a common topic in patient discussions. Issues like fatigue, dizziness, and swelling are often mentioned. These concerns can affect medication adherence, with some users reporting an unusual adjustment period as their bodies adapt.
Adherence rates can vary widely, depending on individual experiences with side effects and perceived effectiveness. Overall, patient satisfaction tends to improve once they find the right dosage and become accustomed to the drug's effects.
Alternatives & Comparison to Diltiazem
In Canada, several alternatives to diltiazem are available for managing hypertension and angina. Notable options include:
- Amlodipine
- Verapamil
These alternatives, while sharing similar effects, differ in their side effects and pharmacokinetics.
| Drug Name | Price | Effectiveness | Safety | Availability |
|---|---|---|---|---|
| Amlodipine | $20 for a one-month supply | Effective for hypertension | Generally safe | Widely available |
| Verapamil | $35 for a one-month supply | Good for angina | May cause constipation | Available in pharmacies |
Healthcare providers often prefer these alternatives due to their unique profiles and patient responses. Discussing options with a healthcare professional can help determine the best fit for individual needs.
Market Overview (Canada) of Diltiazem
When it comes to obtaining diltiazem in Canada, pharmacies like Shoppers Drug Mart and Catena are popular spots. Most chain and independent pharmacies carry diltiazem, ensuring that patients have access to this essential medication.
The pricing for diltiazem varies based on the formulation and the pharmacy but generally falls in the range of CAD 20 to CAD 80 for a month’s supply. Extended-release forms tend to be on the higher end, while generic options offer a more budget-friendly alternative.
In terms of packaging, diltiazem is available in various formats. This includes film-coated tablets, often packed in blisters of 10 or 30. Extended-release capsules can be found in cartons, while injectable forms are provided in vials for hospital use. Creams for topical application also come in easy-to-use tubes.
Regarding demand patterns, diltiazem sees consistent use among chronic condition patients, particularly for hypertension and angina management. Seasonal fluctuations aren't heavily noted, but there’s a slight uptick in demand during colder months, possibly due to changes in physical activity levels and stress, which can exacerbate heart conditions.
Research & Trends Related to Diltiazem
Recent clinical trials and meta-analyses from 2022 to 2025 have focused on diltiazem's role in managing hypertension and its efficacy in heart rate control in patients with atrial fibrillation. Findings show promising results in reducing hospital readmission rates when used in combination with standard therapies.
Additionally, there's growing interest in the experimental uses of diltiazem beyond cardiovascular conditions. Research is being conducted on its potential benefits for migraine treatment and its topical application for anal fissures, with preliminary results indicating effectiveness.
As for the patent status, diltiazem is now available in generic forms across Canada, making it accessible for more patients. This shift from brand-name formulations has led to a decrease in prices, promoting broader usage among individuals who require long-term treatment for their conditions.
Guidelines for Proper Use of Diltiazem
Timing and dosage play a crucial role when taking diltiazem. It's recommended to take it around the same time each day. Some formulations should be taken with food to increase absorption, while others can be taken on an empty stomach. Always follow healthcare provider instructions.
Certain items should be avoided while using diltiazem. Alcohol can heighten side effects, so it's wise to limit or avoid it entirely. Other medications, particularly those that affect heart rate or blood pressure, may interact negatively with diltiazem; always consult a healthcare professional before combining treatments.
Proper storage is essential to maintaining the efficacy of diltiazem. Tablets should be kept at room temperature, away from moisture and light. Injectable forms need specific temperature controls as indicated by the manufacturer.
Be aware of common mistakes that can occur, such as skipping doses or accidentally doubling up. Clear communication with healthcare providers and a strict dosing schedule can help avoid such issues.
Finally, reading the patient information leaflet and following physician guidance is fundamental for safe and effective use of diltiazem. It provides valuable insights about the medication, including potential side effects and essential usage tips.