Calan
Calan
- In our pharmacy, you can buy Calan with a prescription, but generic options like Verapamil are available in most regions without one.
- Calan is used for the treatment of hypertension, angina pectoris, and certain arrhythmias. It works as a calcium channel blocker, helping to relax blood vessels and improve blood flow.
- The usual dosage for adults is 80–120 mg three times a day for hypertension or 180–240 mg once or twice daily for extended-release formulations.
- The form of administration includes tablets, extended-release tablets, and intravenous solutions.
- The effect of the medication begins within 30 to 60 minutes when taken orally.
- The duration of action is typically 6–8 hours for immediate-release forms and up to 24 hours for extended-release formulations.
- It is advisable not to consume alcohol while taking Calan, as it may increase side effects.
- The most common side effect is constipation.
- Would you like to try Calan without a prescription?
Calan
Basic Calan Information
- INN (International Nonproprietary Name)
- Brand names available in Canada
- ATC Code
- Forms & dosages (e.g., tablets, injections, creams)
- Manufacturers in Canada
- Registration status in Canada
- OTC / Rx classification
International Nonproprietary Name (INN)
The medication known as Verapamil serves a critical role in managing various cardiovascular conditions.
Brand Names and Regional Availability
In Canada and globally, Verapamil is available under several brand names. Here's a concise overview:
| Brand Name | Country / Region | Notable Packaging |
|---|---|---|
| Calan | US (discontinued) | Tablets, SR (sustained-release) |
| Calan SR | US | Extended-release tablets |
| Isoptin SR | Canada, Europe | Sustained-release tablets |
| Covera-HS | US | Extended-release evening tabs |
| Verelan | US | Extended-release capsules |
| Verelan PM | US | Evening release capsules |
| Other | Worldwide | Generic Verapamil |
ATC Code
Verapamil is classified under the ATC code C08DA01, which denotes its belonging to the cardiovascular system category. The breakdown is as follows:
- C: Cardiovascular system
- 08: Calcium channel blockers
- D: Phenylalkylamine derivatives
- A01: Verapamil
Pharmaceutical Forms & Dosages
Verapamil is available in various pharmaceutical forms and dosages, suited for different treatment needs. Below is a table of its common forms and their respective dosages.
| Form | Common Dosages |
|---|---|
| Tablets | 40 mg, 80 mg, 120 mg |
| Extended-release tablets | 120 mg, 180 mg, 240 mg |
| Extended-release capsules | 100 mg, 120 mg, 180 mg, 240 mg |
| Intravenous solution (US) | 2.5 mg/mL (5 mg/2 mL ampoules) |
Manufacturers and Suppliers
Various global manufacturing companies, such as Abbott, Pfizer, and Mylan, produce Verapamil. In Canada, local suppliers may vary, and details on their registration should be checked via Health Canada's database.
Regulatory & Approval Status
Verapamil is available by prescription only (Rx) in Canada and several other regions. In the United States, the FDA has approved it for both oral and intravenous use, while European regulations similarly approve its use under the brand name or as Verapamil. Always consult the FDA or your local health authority for the latest information.
Dosage & Administration
Understanding the proper dosage and administration of Calan (verapamil) is crucial for effective treatment. Here’s a concise overview of typical dosages based on various conditions:
| Condition | Adults (Typical Dose) | Pediatric Use | Elderly | Renal/Liver Impairment |
|---|---|---|---|---|
| Hypertension | 80–120 mg PO 3×/day (IR); 180–240 mg 1–2×/day (ER/SR) | Dosing individualized; generally lower starting dose | Lower initial and maintenance dose recommended | Use lower doses; titration required |
| Angina | 80–120 mg PO 3×/day | Not standard | Titrate cautiously | Adjust dose as advised |
| Arrhythmias (IV) | 5–10 mg IV; repeat after 30 min | Specialized use | Reduce dose; monitor heart rate | Cautious use, especially in severe impairment |
Adjustments may also be necessary for specific populations:
- Pediatrics: Use only under specialist care, starting with the lowest effective dose.
- Elderly: Begin treatment at lower doses to account for sensitivity and possible impairment issues.
- Renal/Liver Issues: Use lower starting doses and monitor closely for effectiveness and adverse effects.
For most conditions, treatment duration is usually chronic, adjusting as necessary. Store Calan at room temperature (15–30°C), protected from light and humidity.
Safety & Warnings
When considering Calan, being aware of safety warnings is paramount.
Absolute Contraindications:
- Severe hypotension (SBP < 90 mmHg)
- Sick sinus syndrome or advanced AV block (without pacemaker)
- Severe heart failure
- Cardiogenic shock
- Hypersensitivity to verapamil or its components
Relative Contraindications:
- Mild to moderate heart failure
- Hepatic or renal impairment
- Bradycardia (resting HR < 50 bpm)
- Caution advised when used with other negative inotropes like beta-blockers
Common Side Effects:
| Mild (frequent) | Moderate (dose-dependent) | Serious |
|---|---|---|
| Constipation | Bradycardia | AV block |
| Dizziness, headache | Edema (ankles/feet) | Hypotension, syncope |
| Nausea, fatigue | Flushing | Significant heart failure symptoms |
Special Precautions:
Pregnant individuals and patients with liver or kidney issues should consult a healthcare professional before use to evaluate potential risks. A black box warning is not specified for Calan, yet due diligence regarding drug interactions should always be practiced.
Patient Experience
User experiences with Calan provide valuable insights into its effectiveness and side effects. On reliable sites like Drugs.com and WebMD, ratings usually highlight a moderate satisfaction level, with an average score around 4 out of 5.
Feedback from community forums often points to positive outcomes for hypertension and angina management, though users report side effects such as constipation and dizziness, leading to mixed reviews on long-term adherence.
Personal anecdotes reflect on medication effectiveness and the challenges faced, especially in maintaining consistent usage. These shared experiences play a critical role in managing expectations and improving overall medication adherence.
Alternatives & Comparison
There are several alternatives to Calan for those needing treatment for hypertension, angina, or arrhythmias. Common alternatives in Canada include:
- Amlodipine
- Diltiazem
- Nifedipine
Here's a brief comparison of these alternatives:
| Medication | Price | Effectiveness | Safety | Availability |
|---|---|---|---|---|
| Amlodipine | Moderate | High | Generally well tolerated | Widely available |
| Diltiazem | Similar to Calan | High | Well tolerated, some side effects | Available in various formulations |
| Nifedipine | Lower | Effective | Monitor for reflex tachycardia | Accessible at most pharmacies |
In Ontario, prescribers tend to prefer Amlodipine due to its efficacy and safety profile, especially among patients with diabetes or other comorbidities. Consultation with a healthcare professional is crucial for personalized treatment decisions.
Market Overview (Canada)
For those looking to obtain Calan, select pharmacies are readily stocked. Chains like Catena and HelpNet are among the common pharmacies where Calan can be found. Inquiring at these locations can save time for patients in need of this medication.
Pricing is another important factor. The average cost of Calan in Canada varies based on the dosage. Typically, prices range around 4 to 20 CAD, depending on whether you choose immediate release or extended-release versions. It’s wise to check with local pharmacies for specific quotes, as prices can fluctuate.
In terms of packaging, Calan comes in various formats, suitable for different preferences. Options include blister packs and bottles, with some formulations made for better controlled-release over time. Each type ensures the medication is just as effective as intended.
Demand patterns have shifted, especially during the COVID-19 pandemic, increasing the use of Calan for chronic conditions. Patients have shown a trend towards maintaining their cardiovascular health actively, leading to a steady demand as more individuals recognize the importance of managing hypertension and associated issues.
Research & Trends
Recent meta-analyses conducted between 2022 and 2025 have reinforced Calan's effectiveness, showing promising results in managing hypertension and various forms of angina. These studies indicate that patients experience a significant reduction in blood pressure and symptoms when adhering to treatment plans that involve Verapamil.
In addition to its common uses, researchers are exploring experimental applications of Verapamil. Novel research continues to surface, hinting at its potential in treating additional cardiovascular conditions and even as a preventative measure for specific types of tachycardia.
The patent status in Canada has allowed for greater accessibility to generics of Verapamil, which is beneficial for patients looking for cost-effective alternatives. The generics market is strong, steering towards affordability while maintaining effective treatment protocols. Increasing availability helps to lessen financial burdens for those dependent on Calan or its counterparts.
Guidelines for Proper Use
Understanding when and how to take Calan is crucial for its effectiveness. This medication should be taken consistently, ideally at the same time every day. It's commonly taken with or without food, but maintaining a routine can foster better adherence.
Interacting substances can impact the efficacy of Calan. Avoiding alcohol is advised due to possible adverse effects and interactions. Additionally, it’s best to consult with a healthcare provider about other medications, as certain combinations can lead to unwanted reactions.
Proper storage of Calan also plays a part in ensuring its effectiveness. Store the medication at room temperature, away from light and humidity, to maintain its integrity.
Patients often make common mistakes with their medication. Missing doses can happen easily, but it’s vital to know not to double up when a dose is forgotten. Taking a moment to review the patient leaflet is always beneficial to stay informed about one's treatment plan.